Gene Therapy Essay -- Biology Medical Biomedical Genetics

Gene Therapy: The New Vaccine ABSTRACT This research paper details what gene therapy is and what it is (and potentially will be) used for. It also describes the gene therapy techniques and delivery methods that have been clinically tested and/or verified by scientists and the ideas that stimulate activity in the field in the race to perfect gene therapy methods and their application, as well as telling about the beginnings of its clinical testing and where this budding technology is headed. Finally, it discusses one last question: Is gene therapy the vaccination of the future? RESEARCH Gene therapy is a biotechnological technique that has recently made significant leaps of progress in the world of scientific research. The theories behind its use have created many new goals and ideas in scientists’ minds, and there is much opportunity for discovery in the field. There are two types of genetic technology that are currently being researched for application in clinical testing and for the cure of certain genetic diseases in humans: somatic cell gene therapy, and germ-line therapy. Somatic cell gene therapy is a development that could potentially eliminate a hereditary disease’s effects in a patient through the injection of genetic material that would fill in for a nonfunctional gene, alter an abnormal one in the patient’s chromosomes, or exchange the defective gene for a new, fully-functioning one (www.ornl.org). Germ-line therapy would be used similarly in embryos’ germ cells, but would have the additional effect of the faulty gene’s permanent eradication so that it could not be passed on to future descendants. There are also multiple types of somatic cell gene therapy. In vivo gene therapy, the most common in clinical testin... ...entists will make many revolutionary discoveries. With this new technology being researched, there’s no telling when the technology will be perfected. Who knows? Someday soon, gene therapy could even be something as commonplace as vaccination. Bibliography: 6 Friedmann, The Development of Human Gene Therapy http://www.ornl.gov/sci/techresources/Human_Genome/medicine/genetherapy.shtml http://www.accessexcellence.org/RC/AB/BA/Gene_Therapy_Overview.html http://asgt.org/news_releases/basics.html http://www.fda.gov/fdac/features/2000/500_gene.html http://www.cancer.gov/cancertopics/factsheet/Therapy/gene (G.T. for Cancer) http://content.nejm.org/cgi/content/short/346/16/1185 (Ex Vivo for X-SCID) http://asgt.org/news_releases/06022005a.html http://genome.gov/13014325 Reilly, Abraham Lincoln’s DNA and Other Adventures in Genetics Turksen, Adult Stem Cells 7

Is Business Ethics Important

Before we discuss the importance of ethics in business, it is very essential to examine a prominent theory when conducting business ethics and that is utilitarianism. This theory accounts for the concepts of duty or obligation, rights, and justice. It is routine that the utilitarianism theory is divided up into two groups. These two groups are that of teleological and deontological theory. The teleological approach deals with consequences. â€Å"It states that whether an action is right or wrong depends on the consequences of that action† (DeGeorge, 2010, P. 2) The deontological theory, in contrast to teleological theories such as utilitarianism, deny that consequences are relevant to determining what we should do. â€Å"Deontologists typically propose that we have a duty to perform certain acts not because of some benefit to ourselves or others, but because of the nature of these actions or the rules from which they follow† (Boatright, 2009, P. 31). According to the te xtbook, individuals who mix the teleological and deontological approaches might be called ethical pluralist.The aforementioned information is very necessary to understand how to answer the question of the importance of ethics in business. The ethical theory provides a baseline for what we expect the standards of ethics to be. It is very apparent that we has human beings would come to a cohesive agreement that business ethics is important. This is because we assume that it is better to be right than wrong, moral than immoral, good than bad or just than unjust. In reality this is not a very acceptable answer because it fails to go into detail why we think it is better.The only evidence proves being good is better than being bad is religion, the government, and our elders. It may seem that this response is an iota short of being loquacious; however, ethics in business can be so ambiguous you have to consider all the variables to understand how ethics are viewed in our culture. The comp lexities of ethics in business are something that even ancient scholars possessed a challenging time understanding how to couple ethics with society. Nevertheless, ethics in business is very important because the rimary goal should be to protect people and society. In my opinion ethics is very important in business especially when it relates to being ethically correct with customers and employees. Customers and employees position themselves as the foundation and framework of any company. Therefore, practicing ethical behavior with those two parties should be considered fundamental. The society in which we live money is the leading force for survival, security, and classism. In most cases this is the motive that drives unethical behavior.Personally, I believe that ethics is very important in business because it holds executives accountable for unethical behavior. Even if you are in business and you have no compassion for the employees employed by the company or the customers, the mer e fact that being unethical in business can sometimes jeopardize the welfare of the company. For example the beech-nut company who were accused of producing bogus apple juice, that in turn was nothing more that sugar water, suffered enormous scrutiny because of their deception to customers and they could not defend whether the apple juice was healthy for babies or not.The lack of ethics that were displayed in this case and the uncertainties regarding the health hazard prevented Beech-Nut from being a company with longevity. In conclusion, having strong ethics in business would be more conducive than detrimental to the company. Therefore, being ethical in business shows society that your company can be trusted and people would be more inclined to do business with your company. Discuss the problem of assigning monetary value to things. How could it be argued that it is? Appropriate to assign monetary value to things like friendship, love, and life?The problem of assigning monetary val ue to things derives from the cost-benefit analysis. The primary use for this method is to use monetary units to articulate the benefits as well as disadvantages of a project. The cost benefit analysis is typically used by economist to determine allocation of resources. The cost benefit analysis has been frowned upon on many different levels. This is because not all costs and benefits have an easily determined monetary value. This is the problem with assigning monetary value to things.This is because placing a dollar value on some goods reduces the perceived value. For example, there are plenty of diamonds that have a price value that exceeds that cost of a college education. Could it be a possibility that consumer’s value diamonds more than a college education? If so that would be preposterous. According to John R. Boatright, some goods that have been place with monetary value have been distorted by various factors, therefore, the price of these goods do not mirror their tru e value. Furthermore, assigning monetary value to things people deem impossible are not impossible.This is because we speak with our dollars. The experts in cost benefit analysis began to dodge the problems with assigning value to noneconomic goods by fostering a technique called shadow pricing. This technique showed experts that even though individuals felt it was inappropriate to come up with an arbitrary number to place value on noneconomic goods, they knew that people would pay for what they value. For example people pay for peace and quiet by means of vacations and suburban living, and people also require higher pay for more risky occupations.In reality, the problem with assigning monetary value to noneconomic goods has many complexities due individuality. Every individual believes and value things differently. It just so happen that some things we come together as a people and cohesively value things on the same level, and because of individuality some values standalone. In op position, it could be argued that it is appropriate to assign monetary value to things like friendship, love and life because some applications of cost benefit analysis require that a value be placed on things like a human life.This is so all of the variables can be in place when determining how much to spend on prenatal care to improve the rate of infant mortality, or reducing the amount of cancer causing emissions from factories to name a few. We even justify the appropriateness of assigning monetary value to love by adding prenuptials to our marital agreements. This exposes the expression that money is valued at a higher level than love. Moreover, friendship is also a noneconomic good that could have monetary value. If you had a friend that asked you for a dollar, more than likely you would allow your friend to have a dollar.However, if you friend asked for five hundred dollars, contingent upon your relationship with that friend five hundred dollars may supersede the way you valu e that friend. What is whistle-blowing? Why might it be considered ethically problematic? Why might it be considered morally justified? According to John Boatright the author of Ethics and the conduct of business six edition, whistle-blowing can be defined as the release of information by a member or former member of an organization that is evidence of illegal and /or immoral conduct in the organization or conduct in the organization that is not in the public interest.This is a very succinct point of view because there are multiple components of whistle-blowing. First, to understand clearly whistle-blowing can only be done by a member of the organization. That member is fully recognized as a whistle-blower once they have observed a crime, notifies the police, and then witnesses in court. In addition, whistle-blowing usually contains information that is nonpublic and the whistle-blower presumes that the nonpublic information that they have will captivate spectators. Furthermore, the evidence usually contains some form of misconduct and inappropriate behavior.Once the whistle-blower has the information, it must be released outside the proper channels of communication. For instance, most companies have a policy to inform upper management if u see suspicious activity to report to them and it will be confidential. Some companies have ombudsman for handling employee complaints. Recognize that whistle-blowing does not have to go public because there are internal whistle-blowers as well as external whistle-blowers. However, whether internal or external whistle-blowing it must be voluntary and it must be quality information that would evoke change.The purpose of whistle-blowing must be undertaken as a moral protest with a motive to correct something that is wrong and not to seek revenge or personal advancement. Whistle blowing could be considered ethically problematic because when you first approach the whistle-blowing concept it lucidly displays disloyalty. It illustr ates an employee employer relationship gone wrong. This would be comparable to a mother broadcasting negative information about a child of theirs. Employees are under obligation to not share information with individuals outside the company, unless protecting oneself or a third party person is involved.Also, whistle-blowing might be considered ethically problematic because as an employer when you extend someone the offer of working for and with your company, you expect them to always be in favor of the best of the company. Sometimes companies mess up and do not want every growing pain to be played out in the public. Whistle-blowing might be considered morally justified because people feel that the whistle-blower is holding the company to the standard that they bought into once they became a member of the organization. Whistle-blowers are also morally justified because they are ultimately protecting the public.They are shedding light on information that we as consumers would have neve r known that that behavior was be exhibited in that specific company. Whistle-blowing is also justifiable when the whistle-blower causing a disturbance that would save lives and protects humanity. Holistically, society will consider a whistle blower reasonable if the consumer felt they have been or would have been affected by the company’s unethical behavior. Is ethics relevant to the role as a manager? Discuss ethical management and the management of ethics. It is of high significance that people comprehend the importance of being ethical.Some argue that being ethical in business is no different than being ethical in private life. There has even be some rationality that all managers need just need to be ethical people and not have any specialized training skills or knowledge in the area of ethics. In my opinion, it is quite radical for people to assume that if you are typically an ethical person you would perform ethically in the role of management. Although we can be in agr eement that there is no separation between business ethics and personal ethics, we must realize that some business situations arise that are not easily addressed by ordinary ethical rules.Ethics is relevant to the role as a manager because sometimes management obligations conflict with personal morals or ethics. Case in point, a manager may be forced into the position of terminating an employee for the good of the company with no regard on the impact that will have on the employee lifestyle. A manager may also conclude that it morally wrong for terminating an employee for inadequate reasoning. However, if that termination is in the best interest of the company, then that termination needs to take place.This could go against personal ethical principles a person might obtain, but for the betterment of the company this is considered ethical behavior Furthermore, when a manager is committed to ethical behavior, they have a responsibility to different parties and must consider a wide ran ge of interest. For example, when a manager rejects the promotion of a friend who happens to be an employee or terminating n employee may be the proper channels to follow, however, all variables are to be considered. Moreover, it is reasonably difficult to understand a manager’s role and their relevance to ethics because we need specific management type.There are several different levels of management, top, middle and lower level management. However, top management are the managers that ethical behavior is expected from the most. This is because high level managers are expected to make ethical decisions about strategy and policies. Ethical management and the management of ethics have very distinctive differences. Ethical management is acting ethical as a manager by doing the right thing. Maintaining proper ethical behavior is conducive for individual success as well as corporate success.Because of ethical misconduct, it has ended promising careers and firms have been extremel y harmed furthermore destroyed by the behavior exhibited by a few individuals. There is an old saying that says â€Å"a few bad apples can spoil the bunch†, which can be translated into ethical management as a few bad mangers can destroy a company. These predicaments result from misconduct or even committing illegal activity. The management of ethics is acting effectively in situations that have an ethical aspect. These situations occur in both the internal and external environment of a business firm.Internally, organizations unite employees together through myriad rules, procedures, policies, and values that must be carefully managed. However, effective organizational functioning also depends on gaining the acceptance of the rules, policies, and other guides, and this acceptance requires a perception of fairness and commitment. In order to practice both ethical management and the management of ethics it is necessary for all managers to possess some specialized knowledge in r egards to ethics. Many ethical issues have a factual background that must be understood.In short, to make sound ethical decisions and to implement them in a corporate environment are skills that come with experience and training. Some managers make mistakes because they fail to see the ethical dimensions of a situation. Other managers are unable to give proper weight to competing ethical factors or to see other people’s perspectives. Thus a manager may settle a controversial question to his or her satisfaction, only to discover that others still disagree. Even the most ethical managers must rethink their own personal beliefs about how business should be conducted.

The Israeli Palestinian Conflict A Long And Storied History

The Israeli-Palestinian conflict has a long and storied history. Israel was created in response to European anti-Semitism, with the ethno-nationalist vision of a Jewish territory of their own. By 1948, approximately 522,000 Jews had migrated to Palestine, most arriving during Hitler’s reign of terror that against Jews. Largely, Palestinians resented being expelled from their lands and bearing the burden of the persecution of European Jews. Consequently, the 1947 UN partition sparked aggression between Jewish and Palestinian militias, which escalated following Israel’s independence in 1948. This marks the beginning of conflict between two distinct populations seeking self-determination. Since then, numerous wars, uprisings and terrorist†¦show more content†¦Consequently, it is also these conflicting narratives that frame the security dilemma and climate of fear within which neither party feels secure without obvious dominance over the other. Culture, narrative and politics While theory may prescribe guidelines within which we may analyse and interact in the international system, in reality we cannot avoid the intersection between politics and cultural history. Even in non-democratic societies, public opinion plays a significant role in the maintenance of peace. Compelling narratives of nationalism and revolution, transmitted through media and the arts, rally people in support of rebel or terrorist groups, inciting uprisings and violent attacks that only escalate insecurities on both sides. Moreover, popular culture facilitates the entrance of these narratives into the international community, shaping public perceptions of the conflict and allowing Palestine and Israel to justify their actions or reaffirm their sovereignty. The Palestinian narrative is one of a stable society uprooted by European Jewish settlers and subsequently subject to unjustified Israeli violence, emphasising â€Å"the history of Palestine, the poignant testimonials of Palestinians living under grievous conditions of occupation or exile or imprisonment, [and] the betrayals by international and national leaders.† Take

Ocean Acidification Definition

The oceans have reduced the effects of global warming for thousands of years by absorbing carbon dioxide. Now the basic chemistry of the oceans is changing because of our activities, with devastating consequences for marine life. What Causes Ocean Acidification? Its no secret that global warming is a major issue. A main cause of global warming is our release of carbon dioxide, primarily through the burning of fossil fuels and the burning of vegetation. Over time, the oceans have helped this problem by absorbing excess carbon dioxide. According to NOAA, the oceans have absorbed nearly half of the fossil fuel emissions weve generated over the past 200 years. As the carbon dioxide is absorbed, it reacts with the ocean water to form carbonic acid. This process is called ocean acidification. Over time, this acid causes the pH of the oceans to decrease, making ocean water more acidic. This can have drastic consequences on corals and other marine life, with cascading impacts on the fishing and tourism industries. More About pH and Ocean Acidification The term pH is a measure of acidity. If youve ever had an aquarium, you know that pH is important, and pH needs to be adjusted to optimal levels for your fish to thrive. The ocean has an optimal pH, too. As the ocean becomes more acidic, it becomes more difficult for corals and organisms to build skeletons and shells using calcium carbonate. In addition, the process of acidosis, or buildup of carbonic acid in body fluids, may affect fish and other marine life by compromising their ability to reproduce, breathe and fight diseases. How Bad is the Ocean Acidification Problem? On a pH scale, 7 is neutral, with 0 the most acidic and 14 the most basic. The historical pH of sea water is about 8.16, leaning on the basic side of the scale.The pH of our oceans has fallen to 8.05 since the beginning of the Industrial Revolution. While this may not seem like a big deal, this is a change greater in magnitude than any time in the 650,000 years before the Industrial Revolution. The pH scale is also logarithmic, so that slight change in pH results in a 30 percent increase in acidity. Another problem is that once the oceans get their fill of carbon dioxide, scientists think the oceans could become a carbon dioxide source, rather than a sink. This means the ocean will contribute to the global warming problem by adding more carbon dioxide to the atmosphere. Effects of Ocean Acidification on Marine Life The effects of ocean acidification can be dramatic and far-reaching, and will affect animals such as fish, shellfish, corals, and plankton. Animals such as clams, oysters, scallops, urchins and corals that rely on calcium carbonate to build shells will have a difficult time building them, and protecting themselves as the shells will be weaker. In addition to having weaker shells, mussels will also have a reduced ability to grip  as the increased acid weakens their byssal threads. Fish will also need to adapt to the changing pH and work harder to remove acid out of its blood, which can impact other behaviors, such as reproduction, growth and food digestion. On the other hand, some animals such as lobsters and crabs may adapt well as their shells become stronger in more acidic water. Many of the possible effects of ocean acidification are unknown or still being studied. What Can We Do About Ocean Acidification? Lowering our emissions will help the ocean acidification problem, even if that just slows the impacts long enough to give species time to adapt. Read the Top 10 Things You Can Do to Reduce Global Warming for ideas on how you can help. Scientists have acted swiftly on this issue. The response has included the Monaco Declaration,  in which 155 scientists from 26 countries declared in January 2009 that: Ocean acidification is accelerating and severe damages are imminent;Ocean acidification will have broad socioeconomic impacts, affecting marine food webs, causing substantial changes in commercial fish stocks and threatening food security for millions of people;Ocean acidification is rapid, but recovery is slow;Ocean acidification can be controlled only by limiting future atmospheric carbon dioxide levels. The scientists called for intense efforts to research the problem, evaluate its impacts and cut emissions drastically to help curb the problem. Sources: Fabry, V.J., Seibel, B.A., Feely, R.A. and J.C. Orr. 2008. . Impacts of ocean acidification on marine fauna and ecosystem processes. ICES Journalof Marine Science, 65: 414–432.Feely, R.A., Sabine, C.L, and V.J. Fabry. 2006. Carbon Dioxide and Our Ocean Legacy. (Online) NOAA Pacific Marine Environmental Laboratory Science Brief. Accessed March 7, 2009.McAuliffe, K. 2008. Ocean Acidification: A Global Case of Osteoporosis. (Online) Discover. Accessed March 7, 2009.Monaco Declaration. 2008. Monaco Declaration on Oceans. Accessed July 21, 2015.Smithsonian Ocean Portal. Ocean Acidification.  Accessed July 21, 2015.

Relationship between Mankind and Our Ecosystems - 967 Words

Our society is concerned about the condition and the relationship between mankind and our ecosystems. As a species we have far suppressed our predators and we have increased in population. We have dominated many of our ecosystems that have been destroyed and severely damaged by mankind. This has lead to societies that have struggled for subsistence. Here in the United States the per capita rate of use is the highest in the world. (M. Kaufmann, R. Graham, D. Boyce, W. Moir, L. Perry, R. Reynolds, R. Bassett, P. Mehlhop, C. Edminster, W. Block, and P. Corn April 4, 2014). It is important for us to recognize that the human interest in ecosystems be observed, even if it requires altering certain human progress to stop within bounds with the physical and biological abilities of an ecosystem. Our thinking today about renewable energy has been fed to us by poor thoughts and misinterpitation of our recent history. An era of industrialization during the nineteenth century was do minated by coal later turning to oil or any other type of natural power. One of the final factors in not switching to renewable energy as fast as we would like to see is the economics for large corporation and nations to stop using fossil fuels. This would be devastating to their investments. America is not ready for that. Even though America and the rest of the world are still quiet dependent on fossil fuels the need for alternative energy is out there. Windmills from the days of oldShow MoreRelatedThe Relevance Of Photosynthesis And Nature1545 Words   |  7 Pagesstreaming to the earth and to store the most elusive of all powers in rigid form.† This turns out to be â€Å"an economic provision to which the existence of mankind is inexorably bound.† (Rabinowitch and Govindjee, 9). 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Community Development free essay sample

Development Planning Lecture 1: Understanding the key concepts of Community, Community Development Economic Development Course Learning Outcomes †¢ Explain the key concepts of social infrastructure in spatial planning †¢ Analyze social infrastructure issues in spatial planning †¢ Identify the various challenges of social infrastructure in spatial planning practices Community †¢ Various definitions: ? People who live within a geographically defined area and who have social and psychological ties with each other and with the place where they live (Mattessich and Monsey, 2004) ?A grouping of people who live close to one another and are united by common interests and mutual aids (National Research Council 1975) †¢ These definitions refer to people and the ties that bind them, then only to geographic locations †¢ It means, without people and the connections/ties, community will be only a collections of buildings and streets. †¢ However community does no t necessarily means â€Å"living physically close to one another†.It also refers to social connections at other than living place such as workplace, sports centre, clubs or groups, or political affiliations. We will write a custom essay sample on Community Development or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page †¢ Community can also be created through special interest or conditions such as disability, gender, belief †¢ In this era of social media (such as FB, Twitter) madness, communities can be created on virtual platform. Community Development (CD) †¢ Community Development is defined and described as.. – the process of developing stronger communities of people and the social and psychological ties they share. The educational process to enable citizens to address problems by group decision-making – Involvement in a process to achieve improvement in some aspect of community life – All these processes will result in an outcome which is the improvement of community capital. Community Capital Human Capital †¢ Labour supply, skills, experience, capabilities Physical Capital †¢ Buildings, streets, infrastructure Financial Capital †¢ Community financial institutions, micro loan funds, community development banksEnvironmental Capital †¢ Natural resources, weather, recreational opportunities Social Capital Social Capital †¢ Social Capital refers to the ability of residents to organize and mobilize their resources for the accomplishment of consensual defined goals †¢ It refers to the extent to which members of a community can work together e ffectively to develop and sustain strong relationships, solve problems and make group decisions, and collaborate effectively to achieve common goalsSocial Capital †¢ Some scholars make distinction between bonding capital and bridging capital †¢ Bonding capital refers to ties within homogenous groups (e. g. races, gender, people with the same economic background) †¢ Bridging capital refers to ties among different groups Community development chains Capacity building process Developing the ability to act Social capital Ability to act Community development outcome Taking action Community improvement Development ready communityEconomic development †¢ Community development and economic development is highly sinergistic. †¢ Community development – a planned effort to produce assets that increase the capacity of residents to improve their quality of life. The assets include: physical, human, social, financial, environmental †¢ Economic development †“ the process of creating wealth through the mobilization of human, financial, capital, physical and natural resources to generate marketable goods and services. The definitions are clearly parallel : community development is to produce and improve assets, economic development is to mobilize these assets which will bring greater benefits for the community ie. more goods, services, jobs etc. †¢ Both types of development are highly dependable on each other as most businesses will look for development-ready communities that are equipped with strong and established communities, good infrastructure, abundant supply of labour, safety, telecommunication etc.Community and economic development chains Community development outcome Taking action Community improvement Development ready community Economic development outcome Job creation Increased income and wealth Increased standard of living Capacity building process Developing the ability to act Social capital Ability to act Economic development process Creating and maintaining ED programs Mobilizing resources The end

Reflection on Platos Allegory of the Cave Reflection free essay sample

Reflection on Platos Allegory of the Cave The Allegory of the Cave starts off as a story told by Socrates to Glaucon. In this story, a group of people live in a cave underground. They are bound and unable to move or turn their heads, and so can only look straight in front of them. Before them is a wall and behind them a fire burns. Others in the cave pass before the fire holding objects which cast shadows on the wall. Later, a prisoner is released and taken to the outside world. At first he recoils from the bright light, but he gradually adjusts until he sees the outside world Just as if he had lived his whole life above ground instead of in a cave. After being set free, I wouldnt return to the cave. Platos Allegory of the Cave is a symbol for the contrasts between ideas and what we perceive as reality. We will write a custom essay sample on Reflection on Platos Allegory of the Cave Reflection or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The prisoners in the cave are as ignorant of the truth as Glaucon was, if he relied solely on what he saw. The prisoners, having lived their whole life in the cave, would ook upon the shadows they saw and recognize them as reality. In the same way, Glaucon and others like him believed what they saw and experienced was in fact the reality of the Universe. Conversely, Plato believed that the truth of the Universe was hidden and that the way to discover it was not through observation of the surrounding world but through logic and reasoning. Most people prefer to remain in chains and to see only shadows of the truth. Only the few and the wise are illing to free themselves from the shackles and look the truth in the face, even if it is blinding at first. The Theory of Forms typically refers to the belief expressed by Socrates in some of Platos dialogues, that the material world as it seems to us is not the real world, but only an image or copy of the real world. Just like the people in the cave, what we perceive as truth, what we were led to believe all our lives could be but a fraction or an imitation of what is actually real.